![]() ![]() Synthetic molecules characterized by structural similarities with natural curare are currently preferred to it. In fact if the respiratory arrest is immediately prevented by artificial respiration, muscle function is resumed. There is therefore a progressive paralysis of different muscles, up to the abdominal muscles and the diaphragm, for which there is respiratory arrest. They act blocking the transmission of nerve impulses at the level of the endplate and are only active if administered by parenteral way. Marini Bettolo e dell'istituto superiore di sanità, Roma, De Vittoria srl, 2013.) ( De Castro P., Marsili D., Il curaro degli Indios dell'amazzonia da veleno a farmaco. ( Curares and timbos, poisons used in the Amazon, 2012.) The active ingredients of Curare are alkaloids of isochinolinic -type in Menispermiaceae, indolic-type in Loganiaceae their activity, however, is identical. The resulting solution was boiled and concentrated to the consistence of a soft extract. Very often other products considered toxic were added to the mixture (snake liver, Capsicum anuum and others). The making of Curare was done using species of the family of Menispermiaceae and Loganiaceae. Only in more recent times Curare was used as war poison. In fact, it causes flaccid paralysis of the animal that dies suffocated but that can be eaten because the poison acts only by parenteral way. It indicates a number of complex products of different botanic and geographical origins, but with the same pharmacological action.Ĭurare was used by natives of Central and South America to poison arrows of blowguns, used to hunt. The term Curare is the phonetic transcription of the local word wurari, from the Carib language of the Macusi Indians of Guyana. Myorelaxing activity of Curare and its use in anesthesia ![]()
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